| Datum | Heim | Gast | Halle | Ergebnis |
|---|
| 10.10.2021, 16:00 | GC Zürich Wildcats | Sion Basket | Im Birch Zürich | 87:49 |
| 16.10.2021, 17:30 | Sion Basket | Vevey Riviera Basket | Salle du Midi | 47:122 |
| 23.10.2021, 17:30 | Morges-Saint-Prex Red Devils | Sion Basket | Cherrat | 84:51 |
| 06.11.2021, 17:30 | Sion Basket | Goldcoast Wallabies | Creusets | 69:87 |
| 11.11.2021, 20:45 | Sion Basket | Centre National du Basket Suisse | Creusets | 93:81 |
| 20.11.2021, 17:30 | BC Bären Kleinbasel | Sion Basket | Dreirosen Halle | 57:58 |
| 26.11.2021, 20:45 | Sion Basket | Pully Lausanne Foxes | Creusets | 64:72 |
| 05.12.2021, 17:30 | Union Lavaux Riviera Basket | Sion Basket | Galeries du Rivage | 85:81 |
| 11.12.2021, 17:30 | Sion Basket | Villars Basket | Creusets | 48:56 |
| 08.01.2022, 17:30 | Sion Basket | Union Lavaux Riviera Basket | EPTS Sion | 91:82 |
| 15.01.2022, 17:30 | Villars Basket | Sion Basket | CS Platy | 60:47 |
| 22.01.2022, 17:30 | Sion Basket | Morges-Saint-Prex Red Devils | Creusets | 72:85 |
| 04.02.2022, 20:30 | Centre National du Basket Suisse | Sion Basket | Vallée Jeunesse | 45:64 |
| 13.02.2022, 16:00 | Sion Basket | Groupe E Académie Fribourg U23 | Creusets | 39:59 |
| 19.02.2022, 17:30 | Vevey Riviera Basket | Sion Basket | Galeries du Rivage | 91:45 |
| 26.02.2022, 17:30 | Sion Basket | GC Zürich Wildcats | Creusets | 77:69 |
| 03.03.2022, 20:30 | Groupe E Académie Fribourg U23 | Sion Basket | St-Léonard | 71:64 |
| 12.03.2022, 17:30 | Pully Lausanne Foxes | Sion Basket | Arnold-Reymond | 99:56 |
| 19.03.2022, 17:30 | Goldcoast Wallabies | Sion Basket | Allmendli | 75:46 |
| 26.03.2022, 17:30 | Sion Basket | BC Bären Kleinbasel | Creusets | 79:82 |